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MOORE, BRADLEY

Professor

Degrees:

  • B.S., University of Hawaii
  • Ph.D., University of Washington

Research Interests:

  • Marine Microbial Biosynthesis and Bioengineering
  • Marine Microbial Genomes
  • Marine Microbial Natural Product Discovery

Courses Recently Taught:

  • SIO 262: Seminr/Marine Natural Products
  • SIO262: Seminr/Marine Natural Products
  • SIO264: Sp Top/Marine Natural Prd Chem

Honors and Awards:

  • Matt Suffness Young Investigator Award, American Society of Pharmacognosy, 2001
  • ACS-PRF Type G Award, 1999

Mentoring:

  • Gulder, Tobias (Post Doc; 2008-)
  • Hook, Michelle (Undergrad; 2008-2008)
  • Lane, Amy (Post Doc; 2008-)
  • Plutchak , Diana (Undergrad; 2008-)
  • Roberts, Alexandra (Post Doc; 2008-)
  • Ryan, Kaity (Post Doc; 2008-)
  • Hearle, Johannes (Other; 2007-2007)
  • Kale, Andrew (Graduate; 2007-)
  • Lechner, Anna (Graduate; 2007-)
  • Mrowczysnki , Tracy (Undergrad; 2007-2008)
  • Nett, Markus (Post Doc; 2007-2008)
  • Wang, Albert (Undergrad; 2007-2007)
  • Kalaitzis, John (Post Doc; 2006-2007)
  • McGlinchey, Ryan (Post Doc; 2006-2008)
  • Wilson, Micheal (Graduate; 2006-)
  • Eustaquio, Alessandra (Post Doc; 2005-)
  • Liu, Yuan (Graduate; 2005-)
  • Schultz, Andrew (Graduate; 2005-)
  • Ziegler, Lisa (Masters; 2005-2006)
  • Winter, Jackie (Graduate; 2004-)
  • Moffitt, Michelle (Post Doc; 2003-2006)
  • Udwary, Daniel (Post Doc; 2003-2007)
  • Becker, Julie (Other; 2002-2004)
  • Cheng, Qian (Graduate; 2002-2007)
  • Hamano, Yoshimitsu (Post Doc; 2002-2003)
  • Izumikawa, Miho (Post Doc; 2001-2005)
  • Kalaitzis, John (Post Doc; 2001-2004)
  • Nilsen, George (Undergrad; 2001-2004)
  • Beer, Laura (Graduate; 2000-2006)
  • Xiang, Longkuan (Post Doc; 2000-2006)
  • Hertweck, Christian (Post Doc; 1999-2000)
  • Shipley, Paul (Post Doc; 1999-2001)
  • Shock, Deanna (Masters; 1999-2000)
  • Hopke, Joern (Post Doc; 1998-2000)
  • Piel, Joern (Post Doc; 1998-1999)
  • Yu, Aiming (Post Doc; 1998-1999)
  • Storkova , Stepanka (Post Doc; 1997-1997)
  • Seng, Dieter (Post Doc; 1996-1997)


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Home Department:
SCH PHARM/PHARM

Mailing Address:
Scripps Institution of Oceanography, UCSD
9500 Gilman Drive
La Jolla CA, 92093
Mail Code: 0208

Email: bsmoore@ucsd.edu


Scripps Scholars Profile: http://scrippsscholars.ucsd.edu/bsmoore

Lab Website: http://moorelab.ucsd.edu
WWW:

Publications:

 top

J. M. Winter, A. Jansma, T. M. Handel, and B. S. Moore, “Formation of the pyridazine natural product azamerone by biosynthetic rearrangement of an aryl diazoketone”, Angew. Chem. Int. Ed. Engl., 48, 767-770 (2009).

B. S. Moore, “Extending the biosynthetic repertoire in ribosomal peptide assembly”, Angew. Chem. Int. Ed. Engl., 47, 9386-9388 (2008).

A. S. Eustáquio, J. Härle, J. P. Noel, and B. S. Moore, “S-Adenosyl-L-methionine hydrolase (adenosine forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases”, ChemBioChem, 9, 2215-2219 (2008).

B. S. Moore, A. S. Eustáquio, and R. P. McGlinchey, “Advances in and applications of proteasome inhibitors”, Curr. Opin. Chem. Biol., 12, 434-440 (2008).

A. S. Worthington, G. H. Hur, J. L. Meier, Q. Cheng, B. S. Moore, and M. D. Burkart, “Probing the compatibility of type II ketosynthase–carrier protein partners”, ChemBioChem, 9, 2096-2103 (2008).

R. P. McGlinchey, M. Nett, A. S. Eustáquio, R. N. Asolkar, W. Fenical, and B. S. Moore, “Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors”, J. Am. Chem. Soc., 130, 7822-7823 (2008).

A. S. Eustáquio and B. S. Moore, “Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome”, Angew. Chem. Int. Ed. Engl., 47, 3936-3938 (2008).

A. Schultz, D.-C. Oh, J. R. Carney, R. T. Williamson, D. W. Udwary, P. R. Jensen, S. J. Gould, W. Fenical, and B. S. Moore, “Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin”, J. Am. Chem. Soc., 130, 4507-4516 (2008).

R. P. McGlinchey, M. Nett, and B. S. Moore, “Unraveling the biosynthesis of the sporolide cyclohexenone building block”, J. Am. Chem. Soc., 130, 2406-2407 (2008).

A. S. Eustáquio, F. Pojer, J. P. Noel, and B. S. Moore, “Discovery and characterization of a marine bacterial SAM-dependent chlorinase”, Nat. Chem. Biol., 4, 69-74 (2008).

Q. Cheng, L. Xiang, M. Izumikawa, D. Meluzzi, and B. S. Moore, “Enzymatic total synthesis of enterocin polyketides”, Nat. Chem. Biol., 3, 557-558 (2007).

D. W. Udwary, L. Zeigler, R. Asolkar, V. Singan, A. Lapidus, W. Fenical, P. R. Jensen, and B. S. Moore, “Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica”, Proc. Natl. Acad. Sci. USA, 104, 10376-10381 (2007).

J. M. Winter, M. C. Moffitt, E. Zazopoulos, J. B. McAlpine, P. C. Dorrestein, and B. S. Moore, “Molecular basis for chloronium-mediated meroterpene cyclization: Cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster”, J. Biol. Chem., 282, 16362-16368 (2007).


Last Modified: Mar 16, 2009