• Home
• About
• ScrippsNews
• Magazine
• Research
• Students
• Ships
• Support Scripps
• Jobs at Scripps
• SIO Only

Hughes, Chambers

Assistant Professor of Chemical Biology

Degrees:

• B.S., Geneseo College (SUNY)
• Ph.D., University of California, Berkeley

Research Interests:

• Marine Microbial Natural Products
• Natural Product Target Identification
• Natural Product Total Synthesis and Semisynthesis

Honors and Awards:

• Roche Biosciences Pre-Doctoral Fellowship
• Eli Lilly Pre-Doctoral Fellowship

Alvarez-Mico, X.; Jensen, P. R.; Fenical, W.; Hughes, C. C. Chlorizidine, A Cytotoxic 5H-Pyrrolo[2,1-a]isoindol-5-one-Containing Alkaloid from a Marine Streptomyces sp. Org. Lett. 2013, 15, 988-991

Yamanaka, K.; Ryan, K. S.; Gulder, T. A. M.; Hughes, C. C.; Moore B. S. Flavoenzyme-Catalyzed Atropo-Selective N,C-Bipyrrole Homocoupling in Marinopyrrole Biosynthesis. J. Am. Chem. Soc. 2012, 134, 12434-12437

______________________________________________________

Yang, M.; Liu, Z.; Hughes, C. C.; Stern, A. M.; Wang, H.; Zhong, Z.; Kan, B.; Fenical, W.; Zhu, J. Bile Salt–induced Intermolecular Disulfide Bond Formation Activates Vibrio cholerae Virulence. Proc. Natl. Acad. Sci. 2013, 110, 2348-2353

Haste, N. M.; Hughes, C. C.; Tran D. N.; Fenical, W.; Jensen, P. R.; Nizet, V.; Hensler, M. E. Pharmacological Properties of the Marine Natural Product Marinopyrrole A against Methicillin-Resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 2011, 55, 3305-3312

Pangerl, M.; Hughes, C. C.; Trauner, D. Total Synthesis of Newbouldine via Reductive N–N Bond Formation. Tetrahedron 2010, 66, 6626-6631

Hughes, C. C.; Fenical, W. Antibacterials from the Sea. Chem. Eur. J. 2010, 16, 12512-12525

Hughes, C. C.; Kauffman, C. A.; Jensen, P. R.; Fenical, W. Structures, Reactivities, and Antibiotic Properties of the Marinopyrroles A-F. J. Org. Chem. 2010, 75, 3240-3250

Hughes, C. C.; Fenical, W. Total Synthesis of the Ammosamides. J. Am. Chem. Soc. 2010, 132, 2528-2529

Hughes, C. C.; Yang, Y.-L.; Liu, W.-T.; Dorrestein, P. C.; La Clair, J. J., Fenical, W. Marinopyrrole A Target Elucidation by Acyl Dye Transfer. J. Am. Chem. Soc. 2009, 131, 12094-12096

Hughes, C. C.; MacMillan, J. B.; Gaudêncio, S. P.; Fenical, W.; La Clair, J. J. Ammosamides A and B Target Myosin. Angew. Chem. Int. Ed. 2009, 48, 728-732

Hughes, C. C.; MacMillan, J. B.; Gaudêncio, S. P.; Jensen, P. R.; Fenical, W. The Ammosamides, Structures of Cell Cycle Modulators from a Marine-Derived Streptomyces sp. Angew. Chem. Int. Ed. 2009, 48, 725-727

Hughes, C. C.; Prieto-Davo, A.; Jensen, P. R.; Fenical, W. The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a Marine Streptomyces sp. Org. Lett. 2008, 10, 629-631

Miller, A. K.; Hughes, C. C.; Kennedy-Smith, J. J.; Gradl, S. N.; Trauner, D. The Total Synthesis of (–)-Heptemerone B and (–)-Guanacastepene E. J. Am. Chem. Soc. 2006, 128, 17057-17062

Bowie, A. L., Jr.; Hughes, C. C.; Trauner, D. Concise Synthesis of (±)-Rhazinilam through Direct Coupling. Org. Lett. 2005, 7, 5207-5209

Hughes, C. C.; Miller, A. K.; Trauner, D. An Electrochemical Approach to the Guanacastepene Skeleton. Org. Lett. 2005, 7, 3425-3428

Hughes, C. C.; Kennedy-Smith, J. J.; Trauner, D. Synthetic Studies toward the Guanacastepenes. Org. Lett. 2003, 5, 4113-4115

Hughes, C.C.; Scharn, D.; Mulzer, J.; Trauner, D. Borane-Ammonia Complexes Stabilized by Hydrogen Bonding. Org. Lett. 2002, 4, 4109-4111

Hughes, C. C.; Trauner, D. The Total Synthesis of (–)-Amathaspiramide F. Angew. Chem. Int. Ed. 2002, 41, 4556-4559

Hughes, C. C.; Trauner, D. Concise Total Synthesis of (–)-Frondosin B Using a Novel Palladium Catalyzed Cyclization. Angew. Chem. Int. Ed. 2002, 41, 1569-1572 (erratum: Angew. Chem. Int. Ed. 2002, 41, 2227)