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GERWICK, LENA

Associate Research Scientist

Lecturer

Degrees:

• B.S., Oregon State University
• Ph.D., Oregon State University

Research Interests:

• Innate Immunity
• Genomics
• Drug Discovery
• Zebrafish

Courses Recently Taught:

• SIO 296: Special Topics/Marine Biology
• SIO242: Marine Biotechnology
• SIO242A: Marine Biotechnology I
• SIO296: Special Topics/Marine Biology
• SIO297: Marine Biology Seminar

Honors and Awards:

• Travel Award from the Academic Senate for speaking engagement at the “Zebrafish as a model for infectious disease and cancer” meeting in Leiden, Holland, 2008
• International Society of Comparative and Developmental Immunology - Travel award to attend international meetings in Williamsburg, Virginia and Cairns, Australia, 1997 and 2000
• OSU Honor Roll, Spring 1992 & Spring 1993 Recipient of Zoology Graduate Research Stipends, 1995-2000
• National Institute of Environmental Health - Training grant (full support), August 1998-August 2000

Mentoring:

• Mascuch, Samantha (Graduate; 2009-)
• Lieske, Kelly (Undergrad; 2008-2010)
• Brunetto, Monica (Undergrad; 2007-2010)
• Villa, Francisco (Post Doc; 2007-2010)
• Carland, Tristan (Graduate; 2006-2011)

Gerwick, L., Demers, N.E. and Bayne, C.J. Modulation of Stress Hormones in Rainbow trout by means of anesthesia, sensory deprivation and receptor blockade. Comparative Biochemistry and Physiology Part A. (1999) 124: 329-334.

Gerwick, L., Reynolds, W.S. and Bayne, C.J. A precerebellin-like protein is part of the acute phase response in rainbow trout, Oncorhynchus mykiss. Developmental and Comparative Immunology. (2000) 24(6-7): 597-607.

Bayne, C.J., Gerwick, L., Fujiki, K., Nakao, M. and Yano, T. Immune - relevant (including acute phase) genes identified in the livers of rainbow trout, Oncorhynchus mykiss, by means of suppressive subtractive hybridization. Developmental and Comparative Immunology. (2001): 25(3):205-17.

Bayne CJ and Gerwick L. The acute phase response and innate immunity of fish. Developmental and Comparative Immunology (2001) 25(8-9):725-43.

Gerwick, L., Steinhauer, R., LaPatra, S., Sandell, T., Ortuno, J., Hajiseyedjavadi, N. and Bayne, C.J. The acute phase response of rainbow trout (Oncorhynchus mykiss) plasma proteins to viral, bacterial and fungal inflammatory agents. Fish and Shellfish Immunology, 2002 12(3):229-42.

Fujiki, K., Gerwick, L., Bayne, C.J., Mitchell, L., Gauley, J., Bols, N.and Dixon, B. Molecular cloning and characterization of rainbow trout (Oncorhynchus mykiss) CCAAT/enhancer binding protein beta. Immunogenetics (2003) 55(4):253-261.

Tilton, SC, Gerwick, LG, Hendricks, JD, Rosato, CS, Corley-Smith G, Givan SA, Bailey GS, Bayne CJ, Williams DE. Use of a rainbow trout oligonucleotide microarray to determine transcriptional patterns in aflatoxin B1-induced hepatocellular carcinoma compared to adjacent liver. Toxicol Sci. (2005) 88(2):319-30.

Gerwick, L., Corley-Smith,G. and Bayne, C. J. Gene transcript changes in individual rainbow trout livers following an inflammatory stimulus. . (2007). Fish and Shellfish Immunology 22:157-171

Gerwick, L., Graham, E., Corley-Smith, G.E., Nakao, M. Watson, J., and Bayne, C.J. Intracranial injections induce local transcription of a gene encoding precerebellin-like protein. Fish Physiology and Biochemistry. (2005). 31:363-372.

Bayne, CJ, Gerwick, L, Wheeler, PA, Thorgaard, GH. Transcriptome profiles of livers and kidneys from three Rainbow trout (Oncorhynchus mykiss) clonal lines distinguish stocks from three allopatric populations. Comp Phys and Biochem Part D, (2006) 1 (4):396-403

Momoda, T.S., Schwindt, A.R., Feist, G.W., Gerwick, L., Bayne, C.J., Schreck. C.B. Gene expression in the liver of rainbow trout, Oncorhynchus mykiss, during the stress response. (2007) Comp Biochem and Phys – Part D 2:303–315

Gerwick, W.H., Coates, RC, Engene, N., Gerwick, L. Grindberg, R.V., Jones, A.C. and Sorrels, C.M. (2008). Giant Marine Cyanobacteria produce exciting potential pharmaceuticals. Microbe (review) 3 (6) : 277-284)

Simmons, T.L, Engene, N., Ureña, L.D, Romero L.I., Ortega-Barría E., Gerwick L., and Gerwick W.H.(2008). Viridamides A and B, lipodepsipeptides with anti-protozoan activity from the marine cyanobacterium Oscillatoria nigro-viridis. Journal of Natural Products 71: 1544-1550. Jones AC, Gerwick L, Gonzalez D, Dorrestein PC, Gerwick WH. Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins. BMC Microbiol. 2009 1;9:247.PMID: 19951434

Gu L, Wang B, Kulkarni A, Gehret JJ, Lloyd KR, Gerwick L, Gerwick WH, Wipf P, Håkansson K, Smith JL, Sherman DH. Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. J Am Chem Soc. 2009 Nov 11;131(44):16033-5.PMID: 19835378 Gu L, Wang B, Kulkarni A, Geders TW, Grindberg RV, Gerwick L, Håkansson K, Wipf P, Smith JL, Gerwick WH, Sherman DH. Metamorphic enzyme assembly in polyketide diversification. Nature. 2009 Jun 4;459(7247):731-5.

Villa FA, Lieske K, Gerwick L. Selective MyD88-dependent pathway inhibition by the cyanobacterial natural product malyngamide F acetate. 2010 Eur J Pharmacol. 10;629(1-3):140-6. Epub 2009 Dec 16.PMID: 20006962

Villa F, Gerwick L. Marine Natural Product Drug Discovery: Leads for treatment of inflammation, cancer, infections, and neurological disorders. (2010). Immunopharmacology and Immunotoxicology. 32(2):228-37. Invited review.

Carland TM, Gerwick L. The C1q domain containing proteins: Where do they come from and what do they do? Dev Comp Immunol 34(8):785-90

Jones AC, Monroe EA, Eisman EC, Gerwick L, Sherman SH, Gerwick WH. The Unique Mechanistic Transformations involved in the Biosynthesis of Modular Natural Products from Marine Cyanobacteria. Natural Products Reviews, 2010