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HILDEBRAND, MARK

Researcher

Degrees:

• B.S., State University of New York, Syracuse NY
• Ph.D., University of Arizona, Tucson, AZ

Research Interests:

• Diatom silicon metabolism and silica cell wall synthesis
• Diatom nanotechnology
• High resolution imaging
• Diatom genomics/transcriptomics and transgenics
• Microalgal lipid metabolism for biofuels production
• Algal biofuels

Courses Recently Taught:

• SIO297: Marine Biology Seminar

Honors and Awards:

• Luigi Provasoli Award for outstanding paper published in Journal of Phycology, 2007.

Mentoring:

• Sarno, Analissa (Undergrad; 2011-2011)
• Traller, Jesse (Graduate; 2011-)
• Yenepalli, Aishwarya (Other; 2011-)
• Abbriano, Raffaela (Graduate; 2010-)
• Davis, Aubrey (Post Doc; 2010-)
• Manandhar Shrestha, Kalpana (Post Doc; 2010-)
• Sanchez, Eva (Graduate; 2010-)
• Schroeder, Tamara (Undergrad; 2010-2011)
• Frymann, Tomas (Undergrad; 2009-2010)
• Schroeder, Julia (Other; 2008-2010)
• Shrestha, Roshan (Post Doc; 2008-)
• Smith, Sarah (Graduate; 2008-)
• Tesson, Benoit (Post Doc; 2008-)
• Abramson, Ronit (Other; 2007-2009)
• Norden-Krichmar, Trina (Graduate; 2007-2010)
• Hoffman, Nicolas (Other; 2004-2005)
• Kelz, Jessica (Other; 2003-2004)
• Thamatrakoln, Kimberlee (Graduate; 2000-2006)

37. Tesson, B., and Hildebrand, M. 2010. Extensive and intimate association of the cytoskeleton with forming silica in diatoms: Control over processes on the meso- and micro-scale. PLoS ONE 5(12): e14300. doi:10.1371

36. Tesson, B., and Hildebrand, M. 2009. Dynamics of cell wall silica morphogenesis in the diatom Cyclotella cryptica: Substructure formation and the role of microfilaments. J. Struct. Biol. 169: 62–74.

35. Hildebrand, M. Holton, G., Joy, D.C., Doktycz, M.J., Allison, D.P. 2009. Diverse and conserved nano- and mesoscalestructures of diatom silica revealed by atomic force microscopy. J. Microscopy, 235: 172-187.

34. Hildebrand, M., Kim, S., Shi,D., Scott, K., Subramaniam, S. 2009. 3D imaging of diatoms with ion-abrasion scanning electron microscopy. J. Struct. Biol. 166:316–328.

33. D. P. Allison, Y. F. Dufrêne, M. J. Doktycz, and M. Hildebrand. 2008. Biomineralization at the Nanoscale: Learning from Diatoms. Methods in Cell Biology, 90:61-86.

32. Hildebrand, M. 2008. Diatoms, Biomineralization Processes, and Genomics. Chemical Reviews 108:4855-4874.

31. A. K. Davis and M. Hildebrand. 2008. A self-propagating system for Ge incorporation into nanostructured silica. Chem.Commun., DOI: 10.1039/b804955f

30. Thamatrakoln, K. Hildebrand, M. 2008. Silicon uptake in diatoms revisited: a model for saturable and nonsaturable uptake kinetics and the role of silicon transporters. Plant Physiol. 146: 1397–1407.

29. Hildebrand, M., Doktycz, M.J., Allison, D.P 2008. Application of AFM to Understanding Biomineral Formation in Diatoms. Eur. J. Physiol. 456:127–137.

28. Hildebrand, M., L. Frigeri, A.K. Davis. 2007. Synchronized growth of Thalassiosira pseudonana (Bacillariophyceae) provides novel insights into cell wall synthesis processes in relation to the cell cycle. J. Phycol.43:730-740.

27. Sudek, S., Lopanik, N.B., Waggoner, L.E., Hildebrand, M., Anderson, C., Liu, H.B., Patel, A., Sherman, D.H., Haygood, M.G. 2007. Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina J. Nat. Prod. 70: 67-74.

26. K. Thamatrakoln & M. Hildebrand. 2007. Analysis of Thalassiosira pseudonana silicon transporters indicates distinct regulatory levels and transport activity through the cell cycle. Eucaryotic Cell. 6: 271–279.

25. M. Hildebrand, E.York, J.I. Kelz, A.K. Davis, L.G. Frigeri, D.P. Allison, M.J. Doktycz. Nano-scale control of silica morphology and three-dimensional structure during diatom cell wall formation. 2006. J. Materials Res. 21:2689-2698.

24. K. Thamatrakoln, A. J. Alverson, & M. Hildebrand 2006. Comparative sequence analysis of diatom silicon transporters: Towards a mechanistic model of silicon transport. J. Phycol. 42, 822–834

23. Davis, A.K., Hildebrand, M., and Palenik, B. 2006. Gene expression induced by copper stress in the diatom Thalassiosira pseudonana. Eucaryotic Cell. 5:1157–1168.

22. Frigeri, L.G., Radabaugh, T.R., Haynes, P.A. and Hildebrand, M. 2006. Identification of proteins from a cell wall fraction of the diatom Thalassiosira pseudonana: Insights into silica structure formation. Mol. Cell. Proteomics 5: 182-193.

21. Kenneth H. Sandhage, Shawn M. Allan, Matthew B. Dickerson, Christopher S. Gaddis, Samuel Shian, Michael R. Weatherspoon, Ye Cai, Gul Ahmad, Michael S. Haluska, Robert L. Snyder, Raymond R. Unocic, Frank M. Zalar, Yunshu Zhang, Robert A. Rapp, Mark Hildebrand, and Brian P. Palenik. Merging Biological Self-Assembly with Synthetic Chemical Tailoring: The Potential for 3-D Genetically-Engineered Micro/nano-devices (3-D GEMS). Int. J. Appl. Ceram. Technol. 2 (4): 2005.

20. Davis, A.K., Hildebrand, M., and Palenik, B. 2005. A stress-induced protein associated with the girdle band region of the diatom Thalassiosira pseudonana. J. Phycol. 41: 577–589.

19. Hildebrand, M. 2005. Cloning and functional characterization of ammonium transporters from the marine diatom Cylindrotheca fusiformis. J. Phycol. 41:105–113.

18. Thamatrakoln, K. and Hildebrand, M. 2005. Approaches for functional characterization of diatom silicic acid transporters. J. Nanoscience and Nanotechnology, 5:158-166.

17. Hildebrand, M. 2005. Prospects of manipulating diatom silica nanostructure. J. Nanoscience and Nanotechnology, 5:146-157.

16. Hildebrand, M., L. Waggoner , H. Liu, S. Sudek, S. Allen, C. Anderson, D. Sherman, and M. Haygood. 2004. bryA: An Unusual Modular Polyketide Synthase Gene from the Uncultivated Bacterial Symbiont of the Marine Bryozoan Bugula neritina Chemistry and Biology, 11:1543-1552.

15. E. Virginia Armbrust, John A. Berges, Chris Bowler, Beverley R. Green, Diego Martinez, Nicholas H Putnam, Shiguo Zhou, Andrew E. Allen, Kirk E. Apt, Michael Bechner, Mark A. Brzezinski, Balbir K. Chaal, Anthony Chiovitti, Aubrey K. Davis, Mark S. Demarest, J. Chris Detter, Tijana Glavina, David Goodstein, Masood Z. Hadi, Uffe Hellsten, Mark Hildebrand, Bethany D. Jenkins, Jerzy Jurka, Vladimir V. Kapitonov, N. Kröger, Winnie W.Y. Lau, Todd W. Lane, Frank W Larimer, J. Casey Lippmeier, Susan Lucas, Mónica Medina, Anton Montsant, Miroslav Obornik, Micaela Schnitzler Parker, B. Palenik, Gregory J. Pazour, Paul M. Richardson, Tatiana A. Rynearson, Mak A. Saito, David C. Schwartz, Kimberlee Thamatrakoln, Klaus Valentin, Assaf Vardi, Frances P. Wilkerson, D. S. Rokhsar. 2004. The genome of the diatom Thalassiosira pseudonana: Ecology, evolution, and metabolism. Science, 309:79-86.

14. Hildebrand, M., L. E. Waggoner, G. E. Lim, K. H. Sharp, C. P. Ridley, and M. G. Haygood. 2004. Approaches to identify, clone, and express symbiont bioactive metabolite genes. Natural Products Reports. 21:122-142.

13. Hildebrand, M. Biological processing of nanostructured silica in diatoms. 2003. Prog. Organic Coatings, 47:256-266.

12. Martin-Jezequel, V., Hildebrand, M., and Brzezinski, M. A. 2000. Silicon metabolism in diatoms: Implications for growth. J. Phycol. 36:821-840.

11. Hildebrand, M. and Dahlin, K. 2000. Nitrate transporter genes from the diatom Cylindrotheca fusiformis (Bacillariophyceae): mRNA levels controlled by nitrogen source and by the cell cycle. J. Phycol. 36:702-713.

10. Hildebrand, M., Dahlin, K., and Volcani, B.E. 1998. Characterization of a silicon transporter gene family in Cylindrotheca fusiformis: Sequences, expression analysis, and identification of homologs in other diatoms. Mol. Gen. Genet. 260: 480-486.

9. Hildebrand, M., Volcani, B.E., Gassmann, W., and Schroeder, J.I. (1997). A gene family of silicon transporters. Nature 385: 688-689.

8. van Waasbergen, L. G., Hildebrand, M., and Tebo, B.M. (1996). Identification and characterization of a gene cluster involved in manganese oxidation by spores of the marine Bacillus sp. strain SG-1. J. Bacteriol. 178: 3517-3530.

7. Hildebrand, M., Higgins, D.R., Busser, K., and Volcani, B.E. (1993). Silicon-responsive cDNA clones isolated from the marine diatom Cylindrotheca fusiformis. Gene 132: 213-218.

6. Hildebrand, M., Hasegawa, P., Ord, R.W., Thorpe, V.S., Glass, C.A., and Volcani, B.E. (1992) Nucleotide sequence of diatom plasmids: Identification of open reading frames with similarity to site-specific recombinases. Plant Mol. Biol. 19:759-770.

5. Jacobs, J.D., Ludwig, J.R., Hildebrand, M., Kukel, A., Feng, T.-Y., Ord, R.W., and Volcani, B.E. (1992) Characterization of two circular plasmids from the marine diatom Cylindrotheca fusiformis: Plasmids hybridize to chloroplast and nuclear DNA. Mol. Gen. Genet. 233: 302-310.

4. Hildebrand, M., Corey, D.K., Ludwig, J.R., Kukel, A., Feng, T.-Y., and Volcani, B.E. (1991) Plasmids in diatom species. J. Bacteriol. 173:5924-5927.

3. Hildebrand, M., Hallick, R.B., Passavant, C.W., and Bourque D.P. (1988). Trans-splicing in chloroplasts; the rps12 loci of Nicotiana tabacum. Proc. Nat'l. Acad. Sci., U.S.A. 85: 372-376.

2. Hildebrand, M., Jurgenson, J.E., Ramage, R.T., and Bourque, D.P. (1985). Derivation of a physical map of chloroplast DNA from Nicotiana tabacum by two-dimensional gel and computer-aided restriction analysis. Plasmid 14: 64-79.

1. Bard, J., Bourque, D.P., Hildebrand, M., and Zaitlin, D. (1985). In vitro expression of chloroplast genes in lysates of higher plant chloroplasts. Proc. Nat'l. Acad. Sci., U.S.A. 82: 3983-3987.

Book Chapters and Popular Press

4. Davis, A.K, and Hildebrand, M. Molecular Processes of Biosilicification in Diatoms. 2007. In: Metal Ions in Life Sciences, Volume 4 Biomineralization. From Nature to Application. H. Sigel and A. Sigel (eds.) Wiley, London, pp. 255-294.

3. Thamatrakoln, K, and Hildebrand, M. Diatom Silicon Transporters. 2006. SCIENCE First Hand, Novosibirsk, Russia, vol.5.

2. Hildebrand, M., and Wetherbee, R. Components and control of silicification in diatoms. 2003. In: Progress in Molecular and Subcellular Biology, Silicon Biomineralization, Mueller, W.E.G. (ed .) Vol. 33. Springer-Verlag, Heidelberg. pp. 11-57.

1. Hildebrand, M. 2000. Silicic acid transport and its control during cell wall silicification in diatoms. In: Biomineralisation of Nano- and Micro-Structures, Baeuerlein, E. (ed.). Wiley-VCH, Weinheim, Germany. pp. 171-188.