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JENSEN, PAUL

Research Scientist

Degrees:

• B.S., Florida Institute of Technology
• M.S., San Diego State University
• Ph.D., UCSD, Scripps Institution of Oceanography

Research Interests:

• Microbial distributions and interactions with marine plants and invertebrates
• Sequence-based approaches to the discovery of natural products from marine microbes.
• Comparative genomics.
• Microbial chemical ecology.
• The distributions, biogeography, and molecular evolution of marine bacteria.

Courses Recently Taught:

• SIO 242B: Marine Biotechnology II
• SIO242: Marine Biotechnology
• SIO262: Seminr/Marine Natural Products
• SIO297: Marine Biology Seminar

Mentoring:

• Freel, Kelle (Graduate; 2006-)
• Penn, Kevin (Graduate; 2006-)

Select publications (of 120 total).

2011

Wilson M, Nam S-J, Gulder T, Kauffman C, Jensen PR, Fenical W, Moore BS. Structure and biosynthesis of the marine streptomycete ansamycin ansalactam A and its distinctive branched chain polyketide extender unit. J. Amer. Chem. Soc. 133:1971–1977.

Eustáquio AS, Nam S-J, Penn K, Lechner A, Wilson, MC, Fenical W, Jensen PR, Moore BS. The discovery of salinosporamide K from the marine bacterium “Salinispora pacifica” by genome mining gives insight into pathway evolution. ChemBioChem. 12:61-64.

2010

Jensen PR. Linking species concepts to natural product discovery in the post-genomic era. J. Ind. Microbiol. Biotechnol. 37:219-224.

Gontang EA, Gaudêncio SP, Fenical W, Jensen PR. Sequence-based analysis of secondary metabolite biosynthesis in marine actinobacteria. Appl. Environ. Microbiol. 76:2487-2499.

Gallagher KA, Fenical W, Jensen PR. Hybrid isoprenoid secondary metabolite production in terrestrial and marine actinomycetes. Curr. Opin. Biotechnol. 21:794-800.

Asolkar RN, Kirklan TN, Jensen PR, Fenical W. Arenimycin, an antibiotic effective against rifamicin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola. J. Antibiot. 63:37-39.

Murphy BT, Narender T, Kauffman CA, Woolery W, Jensen PR, Fenical W. Saliniquinones A-F, new members of the highly cytotoxic anthraquinone-gamma-pyrones from the marine actinomycete Salinispora arenicola. Aust. J. Chem. 63:929–934.

Haste NM, Perera V., Maloney KN, Tran DN, Jensen PR, Fenical W, Nizet V, Hensler ME. Activity of the antibiotic etamycin for activity against methicillin-resistant Staphylococcus aureus. J. Antibiot. 63:219-224.

Nam S-J, Gaudencio SP, Kauffman CA, Jensen PR, Kondratyuk TP, Marler LE, Pezzuta JM, Fenical W. Fijiolides A and B, inhibitors of TNF-α-induced NFΚB activation, from a marine-derived sediment bacterium of the genus Nocardiopsis. J. Nat. Prod. 73:1080-1086.

2009

Penn K, Jenkins C, Nett M, Udwary DW, Gontang EA, McGlinchey RP, Foster B, Lapidus A, Podell S, Allen EE, Moore BS, Jensen PR. Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria. The ISME Journal. 3:1193-1203. PMCID2749086.

Hughes CC, MacMillan JB, Gaudencio SP, Jensen PR, Fenical W. The ammosamides: structures of cell cycle modulators from a marine-derived Streptomces sp. Angew. Chem. Int. Ed. 48:725-727.

Asolkar RN, Freel KC, Jensen PR, Fenical W, Kondratyuk TP, Park E-J, Pezzuto JM. Arenamides A–C, Cytotoxic, NFκB Inhibitors from the Marine Actinomycete Salinispora arenicola. J. Nat. Prod. 72:396–402.

Fenical W, Jensen PR, Palladino MA, Lam KS, Lloyd GK, Potts BC. Discovery and development of the anticancer agent salinosporamide A (NPI-0052). Bioorg. Med. Chem. 17:2175-2180.

2008

Jensen PR, Lauro FM. An assessment of actinobacterial diversity in the marine environment. Antonie van Leeuwenhoek 94:51-62.

Prieto-Davó A, Fenical W, Jensen PR. Comparative actinomycete diversity in marine sediments. Aquat. Microbial Ecol. 52:1-11.

Hughes CC, Prieto-Davo A, Jensen PR, Fenical W. The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp. Org. Lett. 10:629-631.

Oh D-C, Gontang EA, Kauffman C, Jensen PR, Fenical, W. Salinipyrones and pacificanones, mixed-precursor polyketides from the marine actinomycete "Salinispora pacifica". J. Nat. Prod. 71:570-575.

Schultz A, Oh D-C, Carney JR, Williamson T, Udwary DW, Jensen PR, Gould SJ, Fenical W, Moore BS. Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin. J. Amer. Chem. Soc. 130:4507-4516. Prudhomme J, McDaniel E, Ponts N, Bertani S, Fenical W, Jensen PR, Le Roch K. Marine actinomycetes: a new source of compounds against the human malaria parasite. PLOS One 3:e2335.

Newton GL, Jensen PR, MacMillan JB, Fenical W, Fahey RC. Low molecular weight thiols produced by a diverse group of marine actinomycetes. Arch. Microbiol. 190:547-557.

2007

Jensen PR, Williams PG, Oh D-C, Zeigler L, Fenical W. Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora. Appl. Environ. Microbiol. 73:1146-1152.

Williams PG, Miller ED, Asolkar RN, Jensen PR, Fenical W. Arenicolides A-C, 26-membered ring macrolides from the marine actinomycete Salinispora arenicola. J. Org. Chem. 72:5025-5034.

Gontang EA, Fenical W, Jensen PR. Phylogenetic diversity of Gram-positive bacteria cultured from marine sediments. Appl. Environ. Microbiol. 73:3272-3282.

Udwary DW, Zeigler L, Asolkar R, Singan V, Lapidus A, Fenical W, Jensen PR, Moore BS. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc. Nat. Acad. Sci. 104:10376-10381.

Gu W, Cueto M, Jensen PR, Fenical W, Silverman RB. Microsporins A and B: new histone deacetylase inhibitors from the marine-derived fungus Microsporum cf. gypseum and the solid-phase synthesis of microsporin A. Tetrahedron 63:6535-6541.

Cho JY, Williams PG, Kwon HC, Jensen PR, Fenical W. Lucentamycins A-D, cytotoxic peptides from the marine-derived actinomycete Nocardiopsis lucentensis. J. Nat. Prod. 70:1321-1328.

2006

Engel SE, Puglisi MP, Jensen PR, Fenical W. Antimicrobial activities of extracts from tropical Atlantic marine plants against pathogens and saprophytes. Mar. Biol. 149:991-1002.

Jensen PR, Mafnas C. Biogeography of the marine actinomycete Salinispora. Environ. Microbiol. 8:1881-1888.

Kwon HC, Kauffman CA, Jensen PR, Fenical W. Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "Marinospora". J. Amer. Chem. Soc. 128:1622-1632.

Oh D-C, Williams PG, Kauffman CA, Jensen PR, Fenical W. Cyanosporasides A and B, cyano- and chloro-cyclopenta [a]indene glycosides from the deep-sea marine actinomycete "Salinispora pacifica". Org. Lett. 8:1021-1024.

Cho JY, Kwon HC, Williams PG, Kauffman CA, Jensen PR, Fenical W. Actinofuranones A and B, polyketides from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales). J. Nat. Prod. 69:425-428.

Puglisi MP, Engel S, Jensen PR, Fenical W. Antimicrobial activities of extracts from Indo-Pacific marine plants against pathogens and saprophytes. Mar. Biol. Early on-line.

Cho JY, Kwon HC, Williams PG, Jensen PR, Fenical W. Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales). Org. Lett. 8:2471-2474.

Cueto M, MacMillan JB, Jensen PR, Fenical W. Tropolactones A-D, four meroterpenoids from a marine-derived fungus of the genus Aspergillus. Phytochem. 67:1826-1831.

Bugni TS, Woolery M, Kauffman CA, Jensen PR, Fenical W. Bohemamine from a marine-derived Streptomyces sp. J. Nat. Prod. 69:1626-1628.

Oh D-C, Jensen PR, Fenical W. Zygosporamide, a cytotoxic cyclic depsipeptide from the marine-derived fungus Zygosporium masonii. Tet. Lett. 47:8625-8628.

Asolkar RN, Jensen PR, Kauffman CA, Fenical W. Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085.

Fenical W, Jensen PR. Developing a new resource for drug discovery: marine actinomycete bacteria. Nat. Chem. Biol. 2:666-673.

2005

Jensen PR, Mincer TJ, Williams PG, Fenical W. Marine actinomycete diversity and natural product discovery. Antonie Leuwenhoek 87:43-48.

Macherla VR, Mitchell SS, Manam RR, Reed KA, Chao T-H, Nicholson B, Deyanat-Yazdi G, Mai B, Jensen PR, Fenical W, Neuteboom STC, Lam KS, Palladino MA, Potts BCM. Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. J. Med. Chem. 48:3684-3687.

Jensen PR, Gontang E, Mafnas C, Mincer TJ, Fenical W. Culturable marine actinomycete diversity from tropical Pacific Ocean sediments. Environ. Microbiol. 7:1039-1048.

Soria-Mercardo I, Prieto-Davo A, Jensen PR, Fenical W. Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomycete. J. Nat. Prod. 68:904-910.

Buchanan GO, Williams PG, Feling RH, Kauffman CA, Jensen PR, Fenical W. Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica. Org. Lett. 7:2731-2734.

Williams PG, Buchanan GO, Feling RH, Kauffman CA, Jensen PR, Fenical W. New cytotoxic salinosporamides from the marine actinomycete Salinispora tropica. J. Org. Chem. 70:6195-6203.

Macherla VR, Mitchell SS, Manam RR, Reed KA, Chao T-H, Nicholson B, Deyanat-Yazdi G, Mai B, Jensen PR, Fenical W, Neuteboom STC, Lsm KS, Palladino MA, Potts BCM. Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. J. Med. Chem. 48:3684-3687.

Oh DC, Jensen PR, Kauffman CA, Fenical W. Libertellenones A-D: Induction of cytotoxic ditrerpenoid biosynthesis by marine competition. Bioorg. Med. Chem. 13:5267-5273. Mincer TJ, Fenical W, Jensen PR. Cultured and culture-independent diversity within the obligate marine actinomycete genus Salinispora. Appl. Environ. Microbiol. 71:7019-7028. Kelly SR, Garo E, Jensen PR, Fenical W, Pawlik J. Effects of Caribbean sponge secondary metabolites on bacterial surface colonization. Aquatic Microbial Ecol. 40:191-203. Maldonado L, Fenical W, Goodfellow M, Jensen PR, Kauffman CK, Ward AC. Salinispora gen nov., sp. nov., Salinispora arenicola sp. nov., and S. tropica sp. nov., obligate marine actinomycetes belonging to the family Micromonosporaceae. Internat. J. System. Evol. Microbiol. 55:1759-1766.