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JENSEN, PAUL

Associate Research Scientist

Degrees:

• B.S., Florida Institute of Technology
• M.S., San Diego State University
• Ph.D., UCSD, Scripps Institution of Oceanography

Research Interests:

• Microbial distributions and interactions with marine plants and invertebrates
• Sequence-based approaches to the discovery of natural products from marine microbes.
• Comparative genomics.
• Microbial chemical ecology.
• The distributions, biogeography, and molecular evolution of marine bacteria.

Courses:

• BISP199: Individual Research for Ugrads
• SIO242: Marine Biotechnology
• SIO262: Seminr/Marine Natural Products
• SIO299: Research

Mentoring:

• Freel, Kelle (Graduate; 2006-)
• Penn, Kevin (Graduate; 2006-)

Since 2005 (of 103 total).

2008

Hughes CC, Prieto-Davo A, Jensen PR, Fenical W. The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp. Org. Lett. 10:629-631.

Oh D-C, Gontang EA, Kauffman C, Jensen PR, Fenical, W. Salinipyrones and pacificanones, mixed-precursor polyketides from the marine actinomycete "Salinispora pacifica". J. Nat. Prod. 71:570-575.

Schultz A, Oh D-C, Carney JR, Williamson T, Udwary DW, Jensen PR, Gould SJ, Fenical W, Moore BS. Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin. J. Org. Chem. 130:4507-4516.

Jensen PR, Lauro FM. An assessment of actinobacterial diversity in the marine environment. Antonie van Leeuwenhoek 94:51-62.

Prieto-Davó A, Fenical W, Jensen PR. Comparative actinomycete diversity in marine sediments. Aquat. Microbial Ecol. 52:1-11.

Prudhomme J, McDaniel E, Ponts N, Bertani S, Fenical W, Jensen PR, Le Roch K. Marine actinomycetes: a new source of compounds against the human malaria parasite. PLOS One 3:e2335.

Fenical W, Jensen PR, Palladino MA, Lam KS, Lloyd GK, Potts BC. Discovery and development of the anticancer agent salinosporamide A (NPI-0052). In press. Bioorg. Med. Chem.

Newton GL, Jensen PR, MacMillan JB, Fenical W, Fahey RC. Low molecular weight thiols produced by a diverse group of marine actinomycetes. In press. Arch. Microbiol.

2007

Jensen PR, Williams PG, Oh D-C, Zeigler L, Fenical W. Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora. Appl. Environ. Microbiol. 73:1146-1152.

Williams PG, Miller ED, Asolkar RN, Jensen PR, Fenical W. Arenicolides A-C, 26-membered ring macrolides from the marine actinomycete Salinispora arenicola. J. Org. Chem. 72:5025-5034.

Gontang EA, Fenical W, Jensen PR. Phylogenetic diversity of Gram-positive bacteria cultured from marine sediments. Appl. Environ. Microbiol. 73:3272-3282.

Udwary DW, Zeigler L, Asolkar R, Singan V, Lapidus A, Fenical W, Jensen PR, Moore BS. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc. Nat. Acad. Sci. 104:10376-10381.

Gu W, Cueto M, Jensen PR, Fenical W, Silverman RB. Microsporins A and B: new histone deacetylase inhibitors from the marine-derived fungus Microsporum cf. gypseum and the solid-phase synthesis of microsporin A. Tetrahedron 63:6535-6541.

Oh D-C, Strangman WK, Kauffman CA, Jensen PR, Fenical W. Thalassospiramides A and B, immunosuppressive peptides from a marine bacterium Thalassospira sp. Org. Lett. In press.

Martin GDA, Tan LT, Jensen PR, Dimayuga RE, Fairchild CR, Raventos-Suarez C, Fenical W. Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces. J. Nat. Prod. 70:1406-1409.

Cho JY, Williams PG, Kwon HC, Jensen PR, Fenical W. Lucentamycins A-D, cytotoxic peptides from the marine-derived actinomycete Nocardiopsis lucentensis. J. Nat. Prod. 70:1321-1328.

2006

Engel SE, Puglisi MP, Jensen PR, Fenical W. Antimicrobial activities of extracts from tropical Atlantic marine plants against pathogens and saprophytes. Mar. Biol. 149:991-1002.

Kwon HC, Kauffman CA, Jensen PR, Fenical W. Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "Marinospora". J. Amer. Chem. Soc. 128:1622-1632.

Oh D-C, Williams PG, Kauffman CA, Jensen PR, Fenical W. Cyanosporasides A and B, cyano- and chloro-cyclopenta [a]indene glycosides from the deep-sea marine actinomycete "Salinispora pacifica". Org. Lett. 8:1021-1024.

Cho JY, Kwon HC, Williams PG, Kauffman CA, Jensen PR, Fenical W. Actinofuranones A and B, polyketides from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales). J. Nat. Prod. 69:425-428.

Jensen PR, Mafnas C. Biogeography of the marine actinomycete Salinispora. Environ. Microbiol. 8:1881-1888.

Puglisi MP, Engel S, Jensen PR, Fenical W. Antimicrobial activities of extracts from Indo-Pacific marine plants against pathogens and saprophytes. Mar. Biol. Early on-line.

Cho JY, Kwon HC, Williams PG, Jensen PR, Fenical W. Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales). Org. Lett. 8:2471-2474.

Cueto M, MacMillan JB, Jensen PR, Fenical W. Tropolactones A-D, four meroterpenoids from a marine-derived fungus of the genus Aspergillus. Phytochem. 67:1826-1831.

Bugni TS, Woolery M, Kauffman CA, Jensen PR, Fenical W. Bohemamine from a marine-derived Streptomyces sp. J. Nat. Prod. 69:1626-1628.

Oh D-C, Jensen PR, Fenical W. Zygosporamide, a cytotoxic cyclic depsipeptide from the marine-derived fungus Zygosporium masonii. Tet. Lett. 47:8625-8628.

Asolkar RN, Jensen PR, Kauffman CA, Fenical W. Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085.

Fenical W, Jensen PR. Developing a new resource for drug discovery: marine actinomycete bacteria. Nat. Chem. Biol. 2:666-673.

2005

Jensen PR, Mincer TJ, Williams PG, Fenical W. Marine actinomycete diversity and natural product discovery. Antonie Leuwenhoek 87:43-48.

Macherla VR, Mitchell SS, Manam RR, Reed KA, Chao T-H, Nicholson B, Deyanat-Yazdi G, Mai B, Jensen PR, Fenical W, Neuteboom STC, Lam KS, Palladino MA, Potts BCM. Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. J. Med. Chem. 48:3684-3687.

Jensen PR, Gontang E, Mafnas C, Mincer TJ, Fenical W. Culturable marine actinomycete diversity from tropical Pacific Ocean sediments. Environ. Microbiol. 7:1039-1048.

Soria-Mercardo I, Prieto-Davo A, Jensen PR, Fenical W. Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomycete. J. Nat. Prod. 68:904-910.

Buchanan GO, Williams PG, Feling RH, Kauffman CA, Jensen PR, Fenical W. Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica. Org. Lett. 7:2731-2734.

Williams PG, Buchanan GO, Feling RH, Kauffman CA, Jensen PR, Fenical W. New cytotoxic salinosporamides from the marine actinomycete Salinispora tropica. J. Org. Chem. 70:6195-6203.

Macherla VR, Mitchell SS, Manam RR, Reed KA, Chao T-H, Nicholson B, Deyanat-Yazdi G, Mai B, Jensen PR, Fenical W, Neuteboom STC, Lsm KS, Palladino MA, Potts BCM. Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. J. Med. Chem. 48:3684-3687.

Oh DC, Jensen PR, Kauffman CA, Fenical W. Libertellenones A-D: Induction of cytotoxic ditrerpenoid biosynthesis by marine competition. Bioorg. Med. Chem. 13:5267-5273. Mincer TJ, Fenical W, Jensen PR. Cultured and culture-independent diversity within the obligate marine actinomycete genus Salinispora. Appl. Environ. Microbiol. 71:7019-7028. Kelly SR, Garo E, Jensen PR, Fenical W, Pawlik J. Effects of Caribbean sponge secondary metabolites on bacterial surface colonization. Aquatic Microbial Ecol. 40:191-203. Maldonado L, Fenical W, Goodfellow M, Jensen PR, Kauffman CK, Ward AC. Salinispora gen nov., sp. nov., Salinispora arenicola sp. nov., and S. tropica sp. nov., obligate marine actinomycetes belonging to the family Micromonosporaceae. Internat. J. System. Evol. Microbiol. 55:1759-1766.