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MOLINSKI, TADEUSZ

Professor

Degrees:

• Ph.D., Monash University, Melbourne, Australia
• B.S., Australian National University

Research Interests:

• Apoptosis
• Cell Cycle Regulation
• Marine Natural Products
• Medicinal Chemistry
• NMR
• Organic Synthesis

Honors and Awards:

• Albert Hofmann Centennial Prize, University of Zürich, 2006
• Cyanamid Faculty Award, 1994

Lievens, S. C.; Hope, H.; Molinski, T. F. “3-Oxo-chol-4-en-24-oic Acids from the Marine Soft Coral Eleutherobia sp.” J. Nat. Prod. 2004, 67(12), 2130-2132.

MacMillan, J. B.; Molinski, T. F. “Majusculoic Acid, a Cyclopropane Containing Fatty Acid from a Marine Cyanobacterial Mat Assemblage” J. Nat. Prod. 2005, 68(4), 604-606.

Masuno, M. N.; Young, D. M.; Hoepker, A. C.; Molinski, T. F. “Addition of Cl2C: to (–)-Menthyl Acrylate Under Sonication-Phase Transfer Catalysis. Efficient Synthesis of (+)-(2-Chlorocyclopropyl)methanol” J. Org. Chem. 2005, 70(10), 4162-4165. Makarieva, T. N.; Denisenko, V. A.; Dmitrenok, P. S.; Guzii, A. G.; Santalova, E. A.; Stonik, V. A.; MacMillan, J. B.; Molinski, T. F. “Oceanalin A, a Hybrid a,w-Bifunctionalized Sphingoid b-Glycoside from the Marine Sponge Oceanapia sp.” Org. Lett. 2005, 7(14), 2897-2900.

Rogers, E. W.; Fernanda de Oliveira, M.; Berlinck, R. G. S.; König, G. M.; Molinski, T. F. “Stereochemical Heterogeneity in Verongid Sponge Metabolites. Absolute Stereochemistry of (+)-Fistularin-3 and (+)-11-epi-Fistularin-3 by Microscale LCMS-Marfey’s Analysis.” J. Nat. Prod. 2005, 68(6), 891-896.

Lievens, S. C.; Molinski, T. F. “Sagittamides A and B. Polyacetoxy Long-Chain Acyl Amino Acids from a Didemnid Ascidian” Org. Lett. 2005, 7(11), 2281-2284.

Ta, T.A.; Feng, W.; Molinski, T. F.; Pessah, I. N. “Hydroxylated Xestospongins Block IP3-Induced Ca2+ Release and Sensitize Ca2+-induced Ca2+ Release Mediated by Ryanodine Receptors” Mol. Pharm. 2005, 69(2), 532-538.

Linington, R. G.; Robertson, M.; Gauthier, A.; Finlay, B. B.; MacMillan, J. B.; Molinski, T. F.; van Soest, R.; Andersen, R. J. “Caminosides B-D, Antimicrobial Glycolipids Isolated from the Marine Sponge Caminus sphaeroconia” J. Nat. Prod. 2006, 69(2), 173-177.

Masuno, M. N.; Pessah, I. N.; Olmstead, M.; Molinski, T. F. “Simplified Cyclic Analogs of Bastadin-5. Structure Activity Relationships for Modulation of the RyR1/FKBP12 Ca2+ Channel” J. Med. Chem. 2006, 49(15), 4497-5011.

Lievens, S. C.; Molinski, T. F. “Progressive-Convergent Elucidation of Stereochemistry in Complex Polyols. The Absolute Configuration of (–)-Sagittamide A” J. Am. Chem. Soc. 2006, 28(36), 11764-11765.

Yang, T.; Esteve, E.; Pessah, I. N.; Molinski, T. F.; Allen, P. D.; López, J. R. “Elevated Resting [Ca2+]i in Myotubes Expressing Malignant Hypothermia RyR1 cDNA’s is Partially Restored by Modulation of Passive Calcium Leak from the Sarcoplasmic Reticulum.” Am. J. Physiol. Cell Physiol. 2007, 61(5), C1591-1598.

Saludes, J. P.; Lievens, S. C.; Molinski, T. F. "Occurrence of the a-Glucosidase Inhibitor 1,4-Dideoxy-1,4-imino-D-arabinitol and Related Iminopentitols in Marine Sponges". J. Nat. Prod. 2007 70(3), 436-438

Rogers, E. W.; Molinski, T. F. “Asymmetric Synthesis of Diastereomeric Diaminoheptanetetraols. A Proposal for the Configuration of (+)-Zwittermicin A” Org. Lett. 2007, 9(3), 437-440.

Skepper, C. K.; MacMillan, J. B.; Zhou, G-X.; Masuno, M. N.; Molinski, T. F. “Chlorocyclopropane Macrolides from the Marine Sponge Phorbas sp. Assignment of the Configurations of Phorbasides A and B by Quantitative CD.”J. Am. Chem. Soc. 2007, 129(14), 4150-4151.

Morinaka, B. I.; Skepper, C. K.; Molinsk, T. F. “Ene-yne Tetrahydrofurans from the Sponge Xestospongia muta. Exploiting a Weak CD Effect for Assignment of Configuration." Org. Lett. 2007, 9(10), 1975-1978.

Rogers, E. W.; Molinski, T. F. “Highly Polar Spiro-Isoxazolines from the Sponge Aplysina fulva”. J. Nat. Prod. 2007, 70(7), 1191-1194.

Schuetz, A.; Junker, J.; Leonov, A.; Lange, O. F.; Molinski, T. F.; Griesinger, C. "Stereochemistry of Sagittamide A from Residual Dipolar Coupling Enhanced NMR." J. Am. Chem. Soc. 2007, 129(xx), xxxx-xxxx, ASAP.

Morinaka, B. I.; Molinski, T. F. "Amaranzole A, a New N-Imidazolyl Steroid from Phorbas amaranthus." Org. Lett. 2007, 9(xx), xxxx-xxxx, ASAP.

Makarieva, T. N.; Dmitrenok, P. S.; Zakarenko, A. M.; Denisenko, V. A.; Guzzi, A. G.; Li, R.; Skepper, C. K.; Molinski, T. F.; Stonik, V. A. "Rhizochalins C and D from the Sponge Rhizochalina incrustata. A Rare threo-Sphingolipid and a Facile Method for Determination of the Carbonyl Position in a,w-Bifunctionalized Ketosphingolipids". J. Nat. Prod. 2007, 70(12), 1991-1998.

MacMillan, J. B.; Xiong-Zhou, G.; Skepper, C. K.; Molinski, T. F. "Phorbasides A-E, Cytotoxic Chlorocyclopropane Macrolide Glycosides from the Marine Sponge Phorbas sp. CD Determination of C-Methyl Sugar Configurations." J. Org. Chem. 2008, 73(10), 3699-3706

Skepper, C. K.; Molinski, T. F. “Long-Chain 2H-Azirines with Heterogeneous Terminal Halogenation from the Marine Sponge Dysidea fragilis. J. Org. Chem. 2008, 73(7), 2592-2597.

Morinaka, B. I.; Molinski, T. F. " Exciton Coupling Circular Dichroism of an Allylic N-imidazolyl Group in Amaranzole A, a Marine Natural Product from Phorbas amaranthus." Chirality 2008, 20, 1066-1070.

Rogers, E. W.; Molinski, T. F. "(+)-Zwittermicin A (ZwA). Assignment of its Complete Configuration by Total Synthesis of the Enantiomer and Implication of D-Serine in its Biosynthesis." Angew. Chem. Intl. Ed. 2008, 47(42), 8086-8089.

Skepper, C. K.; Dalisay, D. S.; Molinski, T. F. "Synthesis and Antifungal Activity of (–)-Z-Dysidazirine". Org. Lett. 2008, 10(22), 5269-5271.

Molinski, T. F.; Dalisay, D. S.; Lievens, S. L.; Saludes, J. P. "Drug Development from Marine Natural Products." Nature Rev. Drug Discov. 2009, 8, 69-85.