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VACQUIER, VICTOR

Professor of Marine Biology

Degrees:

  • B.A., San Diego State University
  • Ph.D., University of California, Berkeley

Research Interests:

  • Fertilization in marine invertebrates
  • Molecular biology of gamete recognition proteins in marine invertebrates
  • Invertebrate immunity
  • Function of homologs of polycystin in sea urchins



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Home Department:
MBRD

Mailing Address:
Scripps Institution of Oceanography, UCSD
9500 Gilman Drive
La Jolla CA, 92093
Mail Code: 0202

Email: vvacquier@ucsd.edu


Scripps Scholars Profile: http://scrippsscholars.ucsd.edu/vvacquier

Publications:

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1998. Concerted evolution in an egg receptor for a rapidly evolving sperm protein. Science 281:710-712.

1998. Evolution of gamete recognition proteins. Science 281:1995-1998.

1998. Increased association of SNAP25 with syntaxin and VAMP following acrosomal exocytosis of sea urchin sperm. Journal of Biological Chemistry 273:24,355-24,359.

1998. Mitochondrial DNA and bindin gene sequence evolution among allopatric species of the sea urchin genus Arbacia. Molecular Biology and Evolution 15:185-195.

2000. Co-localization of receptor and transducer proteins in the glycosphingolipid-enriched, low density, detergent-insoluble membrane fraction of sea urchin sperm. Glycoconjugate Journal 17:205-214.

2001. Abalone sperm lysin: The dissolving and evolving sperm protein. BioEssays 23:95-103.

2001. Polymorphism in abalone fertilization proteins is consistent with the neutral evolution of the egg's receptor for lysin (VERL) and positive Darwinian selection of sperm lysin. Molecular Biology and Evolution 18(3):376-383.

2001. The crystal structure of a fusagenic protein reveals extreme surface properties. Biochemistry 40:5407-5413.

2002. A flagellar K+ dependent Na+/Ca++ exchanger keeps Ca++ low in sea urchin spermatozoa. Proceedings of the National Academy of Sciences of the United States of America

2002. High molecular mass egg fucose sulfate polymer is required for opening both Ca2+ channels involved in triggering the sea urchin sperm acrosome reaction. Journal of Biological Chemistry 277:1182-1189.

2002. SuREJ3, a polycystin-1 protein, is cleaved at the GPS domain and localizes to the acrosome region of sea urchin sperm. Journal of Biological Chemistry 11:943-948.

2002. The rapid evolution of reproductive proteins. Nature Reviews in Genetics 3:137-143.