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FENICAL, WILLIAM

Distinguished Professor

Director, CMBB

Degrees:

• B.S., California State Polytechnic University
• M.S., San Jose State University
• Ph.D., University of California, Riverside

Research Interests:

• Chemistry of marine plants, microorganisms and invertebrate animals.
• Utilization of marine-derived compounds for the treatment of various human diseases, in particular cancer and infectious diseases.

Courses Recently Taught:

• SIO 262: Marine Chemical Biology Seminr
• SIO 296: Special Topics/Marine Biology
• SIO262: Seminr/Marine Natural Products

Honors and Awards:

• Elected as Fellow of the American Association of Science, 2008
• Honored Alumnus for the College of Science and Mathematics, California State University, San Luis Obispo, CA, 2007
• Distinguished Alumnus of the Year, University of California, Riverside, 2006
• Elected Fellow of the American Society of Pharmacognosy, 2006
• Ernest Guenther Award in Natural Products Chemistry, 2006
• Lifetime Achievement Award from the American Society of Pharmacognosy, 2006
• Appointed as “Distinguished Professor of Oceanography”, SIO, 2005
• NCI Merit Award from the NIH, National Cancer Institute, 2003
• Burroughs Wellcome Visiting Professorship in Microbiological Sciences (University of Guam), 2002
• Silver Medal Award in Chemical Ecology, 1997
• Paul Scheuer Award in Marine Natural Products Chemistry, 1996
• Distinguished Alumni Award, University of California, Riverside, 1994
• Senior Queen's Fellowship, in Marine Science, Australian Commonwealth Government, 1984

Mentoring:

• Alvarez, Xavier (Post Doc; 2008-)
• Loesgen, Sandra (Post Doc; 2008-)
• Sun, Peng (Post Doc; 2008-)
• Fukuda, Takashi (Post Doc; 2007-)
• Gaudencio, Susana (Post Doc; 2007-)
• Murphy, Brian (Post Doc; 2007-)
• Nam, Sang Jip (Post Doc; 2007-)
• Maloney, Katherine (Post Doc; 2006-)
• Hughes, Chamgers (Post Doc; 2005-)
• Kemmler, Michael (Post Doc; 2004-2005)
• Macmillan, John (Post Doc; 2004-2006)
• Asolkar, Ratnakar (Post Doc; 2003-2008)
• Bugni, Timothy (Post Doc; 2003-2004)
• Cho, Ji Young (Post Doc; 2003-2005)
• Martin, Glenroy (Post Doc; 2003-2005)
• Williams, Philip (Post Doc; 2003-2006)
• Espindola, Anna Paula (Graduate; 2002-2008)
• Gontang, Erin (Graduate; 2002-2008)
• Kwon, Hak Cheol (Post Doc; 2002-2006)
• Prieto-Davo, Alejandra (Graduate; 2002-2008)
• Strangman, Wendy (Graduate; 2002-2007)
• Boonlarppradab, Chollaratt (Graduate; 2001-2007)
• Folmer, Florence (Masters; 2001-2003)
• Krishna, Chundakkadu (Post Doc; 2001-2002)
• Miller, Eric (Graduate; 2001-2007)
• Mustra, David (Post Doc; 2001-2002)
• Oh, Dong-Chan (Graduate; 2001-2006)
• Puglisi, Melany (Post Doc; 2001-2002)
• Tan, Lik (Post Doc; 2001-2003)
• Turkson, Nicole (Graduate; 2001-2007)
• Buchanan, Greg (Post Doc; 2000-2003)
• Feling, Robert (Post Doc; 2000-2002)
• Garo, Eliane (Post Doc; 2000-2003)
• Kiebooms, Raphael (Post Doc; 2000-2001)
• Sandler, Joel (Graduate; 2000-2005)
• Ridley, Christian (Graduate; 1999-2005)
• Shin, Hee Jae (Post Doc; 1999-2000)
• Cueto, Mercedes (Post Doc; 1998-2001)
• Flachsmann, Felix (Post Doc; 1998-2000)
• Kubanek, Julia (Post Doc; 1998-2000)
• Mincer, Tracy (Graduate; 1998-2004)
• Oh, Hyuncheol (Post Doc; 1998-2000)
• Sakata, Solange (Post Doc; 1998-2000)
• Schellhaas, Kurt (Post Doc; 1998-1999)
• Spyere, Allan (Masters; 1998-2004)
• Eckdahl, Anja (Post Doc; 1997-1998)
• Lee, Choong Hwan (Post Doc; 1997-1998)
• Lerch, Melissa (Graduate; 1997-2003)
• Lin, Xinajian (Post Doc; 1997-1998)
• Lorenz, Peter (Post Doc; 1997-1998)
• Belofsky, Gil (Post Doc; 1996-1998)
• Liu, Zimin (Post Doc; 1996-1997)
• Renner, Matthew (Post Doc; 1996-1998)
• Son, Byeng Wha (Post Doc; 1996-1997)
• Hardt, Ingo (Post Doc; 1995-1997)
• Kanjana-opas, Akkharawit (Graduate; 1995-2002)
• Puyana, Monica (Graduate; 1995-2001)
• Rowley, David (Graduate; 1995-2001)
• Wilson, Dean (Post Doc; 1995-1997)
• Eve, Tegan (Graduate; 1994-2001)
• Vervoort, Helene (Graduate; 1994-1999)
• Cheng, Xing (Post Doc; 1993-1998)
• Jenkins, Kelly (Graduate; 1993-1998)
• Koeck, Matthias (Post Doc; 1993-1995)
• Toske, Steve (Post Doc; 1993-1995)
• Kim, Young-Kyoon (Post Doc; 1992-1994)
• Lindel, Thomas (Post Doc; 1992-1994)
• Frankmoelle, Walter (Post Doc; 1991-1993)
• Lee, Nam-Kyung (Post Doc; 1991-1993)
• Shen, Ya-Shing (Post Doc; 1991-1992)
• Wahl, Martin (Post Doc; 1991-1993)
• Boehler, Mark (Post Doc; 1990-1992)
• D'Ambrosio, Michele (Post Doc; 1989-1990)
• Kang, Heonjoong (Graduate; 1989-1994)
• Montanari, Antonio (Post Doc; 1989-1991)
• Pathirana, Charles (Post Doc; 1989-1991)
• Richards-Gross, Sarah (Masters; 1989-1993)
• Hagmann, Leonard (Post Doc; 1988-1989)
• Pochapsky, Susan (Post Doc; 1988-1989)
• Trischman, Jacqueline (Graduate; 1988-1993)
• Boyd, Thomas (Graduate; 1987-1993)
• Park, Minkyu (Masters; 1987-1990)
• Risk, Martin (Post Doc; 1987-1988)
• Roussis, Vasillios (Post Doc; 1987-1989)
• Tapiolas, Dianne (Post Doc; 1987-1989)
• Harrison, Kevin (Masters; 1986-1989)
• Wu, Zhongde (Post Doc; 1986-1987)
• Ciminiello, Patrizia (Post Doc; 1985-1986)
• Quinney, Russell (Masters; 1985-1986)
• Gustafson, Kirk (Post Doc; 1984-1987)
• Groweiss, Amiram (Post Doc; 1983-1985)
• Lindquist, Niels (Graduate; 1983-1989)
• Shin, Jongheon (Graduate; 1983-1989)
• Burch, Mark (Masters; 1982-1986)
• Francisco, Christian (Post Doc; 1982-1982)
• Gil-Turnes, Maria (Graduate; 1982-1988)
• Banaigs, Bernard (Post Doc; 1981-1982)
• Sato, Aiya (Post Doc; 1981-1983)
• Bowden, Bruce (Post Doc; 1980-1981)
• Paul, Valerie (Graduate; 1980-1985)
• Izac, Richard (Post Doc; 1979-1981)
• Schneider, Phillipe (Post Doc; 1979-1980)
• Withers, Nancy (Post Doc; 1978-1979)
• Bandurraga, Maury (Graduate; 1977-1982)
• Look, Sally (Graduate; 1977-1983)
• Sun, Hao H. (Post Doc; 1977-1979)
• Gerwick, William (Graduate; 1976-1981)
• Kokke, Wilhelmus (Post Doc; 1976-1980)
• Rosen, William M. (Post Doc; 1976-1977)
• Young, David N. (Post Doc; 1976-1977)
• McEnroe, Frank J. (Post Doc; 1975-1977)
• Sleeper, Howard (Post Doc; 1975-1977)
• Stallard, Martha O. (Post Doc; 1975-1977)
• Howard, Bruce (Graduate; 1974-1978)
• McConnell, Oliver (Graduate; 1974-1979)

Listed are 111 publications of 385:

1998

New Cytotoxic Sesquiterpenoid Nitrobenzoyl Esters from a Marine Isolate of the Fungus Aspergillus versicolor. Tetrahedron 54, 1715-1724. [G. N. Belofsky, P. R. Jensen, M. K. Renner, and W. Fenical* ]

Evidence that a New Antibiotic Flavone Glycoside Chemically Defends the Seagrass Thalassia testudinum Against Zoosporic Fungi. Appl. Env. Microbiol. 64(4), 1490-1496. [P. Jensen, K. Jenkins, D. Porter and W. Fenical].

Guaymasol and Epiguaymasol: Aromatic triols from a Deep-Sea Bacillus isolate. Nat. Prod. Lett. 11, 279-284. [J. A. Trischman, P. R. Jensen and W. Fenical*]

Mactanamide, a New Fungistatic Diketopiperazine Produced by a Marine Aspergillus sp. Nat. Prod. Lett. 12, 55-60. [P. Lorenz, P. R. Jensen and W. Fenical].

Pharmacological Characterization of the Pseudopterosins: Novel Anti-Inflammatory Natural Products Isolated from the Caribbean Soft Coral Pseudopterogorgia elisabethae. Life Sciences Pharmacology Letters, 62(26), 401-407. [A. M. S. Mayer, P. B. Jacobson, W. Fenical, R. S. Jacobs and K. B. Glaser].

Natural Products from the Gorgonian Lophogorgia punicea : Isolation and Structure Elucidation of an Unusual 17-Hydroxy Sterol. J. Brazil. Chem. Soc. 9(2), 187-195. [Lenize F. Maia, Angelo C. Pinto, Rosângela de A. Epifanio, Ingo Hardt, and William Fenical.]

Chemical Defense of the Caribbean Ascidian Didemnum conchyliatum. Mar. Ecol. Prog. Series. 164, 221-228. [H. C. Vervoort, J. R. Pawlik and W. Fenical]

Exumolides A and B: Antimicroalgal Cyclic Depsipeptides Produced by a Marine Fungus of the Genus Scytalidium. Tetrahedron Lett. 39, 2463-2466. [K. M. Jenkins, M. K. Renner, P. R. Jensen and W. Fenical]

Marine Microbial Chemical Ecology, Bioassays with Marine Microorganisms: Volume II in Methods in Chemical Ecology, K. F. Haynes and J. Millar Eds. [K. M. Jenkins, P. R. Jensen and W. Fenical] pps. 1-38.

Eleutherobin, A Novel Cytotoxic Agent that Induces Tubulin Polymerization similar to Paclitaxel (Taxol). Cancer Research 58, 1111-1115. [B. H. Long, J. M. Carboni, A. J. Wasserman, L. A. Cornell. A. M. Casazza, P. R. Jensen, W. Fenical and C. R. Fairchild]

Chemical Defenses of Freshwater Macrophytes Against Crayfish Herbivory. J. Chem. Ecol. 24 (10), 1639-1658. [R. C. Bolser, M. E. Hay, N. Lindquist, W. Fenical and D. M. Wilson].

Aspergillamides A and B: Modified Cytotoxic Tripeptides Produced by a Marine Fungus of the Genus Aspergillus. Tetrahedron 54, 13459-13466. [S. G. Toske, P. R. Jensen, C. A. Kauffman and W. Fenical]

Neomangicols: Structures and Absolute Stereochemistries of Unprecedented Halogenated Sesterterpenes from a Marine Fungus of the Genus Fusarium. J. Org. Chem. 63, 8346-8354. [M. K. Renner, Paul R. Jensen, and W. Fenical*]

Solanapyrones E-G, Antialgal Metabolites Produced by a Marine Fungus. Phytochemistry 49, 2299-2304. [K. M. Jenkins, S. G. Toske, P. R. Jensen and W. Fenical*]

1999

A Cyclized Didemnimide Alkaloid from the Caribbean Ascidian Didemnum conchyliatum. J. Nat. Prod. 62, 389-391. [H. C. Vervoort, W. Fenical and P. A. Keifer]

Sansalvamide: A New Cytotoxic Cyclic Depsipeptide Produced by a Marine Fungus of the Genus Fusarium. Tetrahedron Letters 40, 2913-2916. [G. N. Belofsky, P. R. Jensen, and W. Fenical]

Arenaric Acid, a New Pentacyclic Polyether Produced by a Marine Bacterium (Actinomycetales). J. Nat. Prod. 62, 605-607. [X. C. Cheng, P. R. Jensen and W. Fenical]

Luisols A and B, New Aromatic Tetraols Produced by an Estuarine Marine Bacterium of the Genus Streptomyces (Actinomycetales). J. Nat. Prod. 62, 608-610. [X. C. Cheng, P. R. Jensen and W. Fenical]

Salinamides, Antiinflammatory Depsipeptides from a Marine Streptomycete. J. Org. Chem. 64, 1145-1150. [B. S. Moore, J. A. Trischman, D. Seng, D. Kho, P. R. Jensen and W. Fenical]

Habenariol, A Freshwater Feeding Deterrent from the Aquatic Orchid Habenaria repens (Orchidaceae). Phytochemistry 50, 1333-1336. [D. M. Wilson, W. Fenical, M. Hay, N. Lindquist and R. Bolser]

New Cytotoxic Epidithiodioxopiperazines Related to Verticillin A from a Marine Isolate of the Fungus Penicillium. Nat. Prod. Lett. 13, 213-222. [B-W. Son, P. R. Jensen, C. A. Kauffman, W. Fenical].

Mechanism of Inhibition of a Poxvirus Topoisomerase by the Marine Natural Product Sansalvamide A. J. Molecular Pharm. 55, 1049-1053. [Y. Hwang, D. Rowley, D. Rhodes, J. Gertch, W. Fenical and F. Bushman].

Lobophorins A and B, New Antiinflammatory Macrolides Produced by a Tropical Marine Bacterium. Bioorg. & Med. Chem. Lett. 9, 2003-2006. [Z.-D. Jiang, P. R. Jensen and W. Fenical].

Chemical defense of the Caribbean reef sponge Axinella corrugata against predatory fishes. J. Chem. Ecol. 25, 2811-2823. [D. M. Wilson, M. Puyana, W. Fenical and J. R. Pawlik].

New Feeding Deterrents, Including a Novel Sesquiterpenoid Heterogorgiolide, from the Brazilian Gorgonian Heterogorgia uatumani (Octocorallia, Gorgonacea). J. Nat. Prod. 62, 1022-1024. [L. F. Maia, R. de A. Epifanio, T. Eve and W. Fenical].

Thraustochytrosides A-C, New Glycosphingolipids from a Unique Marine Protist, Thraustochytrium globosum. Tetrahedron Lett. 40, 7637-7640. [K. M. Jenkins, P. R. Jensen and W. Fenical]

Antimicrobial Activity of Caribbean Sponge Extracts. Aquatic Microbial Ecology 19, 279-284. [R. W. Newbold, P. R. Jensen, W. Fenical, and J. R. Pawlik]

Cyclomarins A-C, New Anti-Inflammatory Cyclic Peptides Produced by a Marine Bacterium (Streptomyces sp.) J. Amer. Chem. Soc. 121, 11273-11276. [M. K. Renner, Y-C Shen, X-C Cheng, P. R. Jensen, W. Frankmoelle, C. A. Kauffman, W. Fenical, E. Lobkovsky and J. Clardy*]

2000

Tamandarins A and B; New Cytotoxic Depsipeptides from a Brazilian Ascidian of the Family Didemnidae. J. Org. Chem. 65, 782-792. [H. Vervoort, R. de A. Epifanio and W. Fenical*]

Neomarinone, and new Cytotoxic Marinone Derivatives Produced by a Marine Filamentous Bacterium (Actinomycetales). Tetrahedron Lett. 41, 2073-2076. [I. H. Hardt, P. R.Jensen and W. Fenical*]

Oxepinamides A-C and Fumiquinazolines H-I: Bioactive Metabolites from a Marine Isolate of a Fungus of the Genus Acremonium. Eur. J. Chem. 6(8), 1355-1360. [G. N. Belofsky, M. Anguera, P. R. Jensen, W. Fenical and M. Köck].

Two Antifeedant Lignans from the Freshwater Macrophyte Saururus cernuus. Phytochem. 54, 281-287. [J. Kubanek, W. Fenical, M. E. Hay, P. J. Brown and N. Lindquist].

Mangicols, Structures and Biosynthesis of a New Class of Sesterterpene Polyols from a Marine Fungus of the Genus Fusarium. J. Org. Chem. 65(16), 4843-4852. [M. K. Renner, P. R. Jensen, W. Fenical*]

Marine Microorganisms and Drug Discovery: Current Status and Future Potential. In: Drugs from the Sea. Fusetani, N., ed.; Basel(Switzerland): Karger, pp 6-29. (158 p.) [P. R. Jensen and W. Fenical*].

New Cytotoxic Sterol Glycosides from the Octocoral Carijoa (Telesto) riisei. J. Nat. Prod. 63(10), 1427-1430. [L. F. Maia, R. de A. Epifanio and W. Fenical].

N-Methylsansalvamide, a cytotoxic cyclic depsipeptide from a marine fungus of the genus Fusarium. Phytochemistry 55, 223-226. [M. Cueto, P. R. Jensen and W. Fenical].

Chemical Defenses of the Endemic Brazilian Gorgonian Lophogorgia violacea Pallas (Octocorallia, Gorgonacea). J. Braz. Chem. Soc. 11(6), 584-591. [R. A. Epifanio, L. F. Maia and W. Fenical].

Triterpene Glycosides Defend the Caribbean Reef Sponge Erylus formosus from Predatory Fishes. Mar. Ecol. Prog. Series 207, 69-77. [J. Kubanek, J. R. Pawlik, T. Eve and W. Fenical].

2001

Lignoid chemical defenses in the freshwater macrophyte Saururus cernuus. Chemoecology 11, 1-8. [J. Kubanek, M. E. Hay, P. J. Brown, N. Lindquist, and W. Fenical]

Pestalone, A New Antibiotic Produced by a Marine Fungus in Response to Bacterial Challenge. J. Nat. Prod. 64, 1444-1446. [M. Cueto, P. R. Jensen, C. Kauffman, W. Fenical, E. Lobowsky and J. Clardy]

New Antifeedant triterpene Glycosides from the Caribbean Sponge Erylus formosus. Nat. Prod. Lett. 15(4), 275-285. [J. Kubanek, W. Fenical and J. R. Pawlik]

2002

Aspergilloxide, A Novel Sesterterpene Epoxide from A Marine-Derived Fungus of the Genus Aspergillus. Organic Letters 4(9), 1583-1858. [M. Cueto, P.R. Jensen, W. Fenical]

Multiple defensive roles for triterpene glycosides from two Caribbean sponges. Oecologia 131, 125-136. [J. Kubanek, K. E. Whalen, S. Engel, S. R. Kelly, T. P. Henkel, W. Fenical, and J. R. Pawlik]

Secondary metabolites from marine fungi, In: Fungi in Marine Environments, (ed. K. D. Hyde), Fungal Diversity Research Series 9, Fungal Diversity Press: Hong Kong, pp 293-315. [P. R. Jensen and W. Fenical]

Widespread and persistent populations of a major new marine actinomycete taxon in ocean sediments, Appl. Envir. Microbiol. 68(10), 5005-5011. [Tracy J. Mincer, Paul R. Jensen, Christopher A. Kauffman, and William Fenical].

Thalassiolins A-C: New marine-derived inhibitors of HIV cDNA Integrase. Bioorg Med. Chem. 10, 3619-3625. [D. M. Rowley, W. Fenical]

Chemical ecology of marine microbial defense. J. Chem. Ecol. 28(10), 1971-1985. [S. Engel, P. R. Jensen and W. Fenical]

Marine microorganisms as a developing resource For drug discovery [W. Fenical, K. M. Sethna,,G. K. Lloyd] Pharmaceutical News 9, 1-6 (2002).

2003

Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial Source, a marine bacterium of the new genus Salinospora. Angew. Chem. Int. Ed. 42(3), 355-357. [R. H. Feling, G. O. Buchanan, T. J. Mincer, C. A. Kauffman, P. R. Jensen and W. Fenical]

Scytalidamides A and B, new cytotoxic cyclic heptapeptides from a marine fungus of the genus Scytalidium J. Org. Chem., 68 (23), 8767 -8773. [L.T. Tan, X. C. Cheng, P. R. Jensen, and W. Fenical]

Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens. J. Nat. Prod. 66(3), 423-426. [E. Garo, P. R. Jensen, W. Fenical, E. Lobkovsky and J. Clardy]

Seaweed resistance to microbial attack: A targeted chemical defense against marine fungi. Proc. Nat. Acad. Sci. 100(12). 6916-6921. [J. Kubanek, P. R. Jensen, P. A. Keifer, M. C. Sullards, D. O. Collins, and W. Fenical]

Diazonamide A and a synthetic structural analog: Disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin. Mol. Pharmacol. 63, 1273-1280. [Z. Cruz-Monserrate, H. C. Vervoort, R. Bai, D. J. Newman, S. B. Howell, G. Los, J. T. Mullaney, M. D. Williams, G. Pettit, W. Fenical and E. Hamel.]

Effects of Caribbean sponge extracts on bacterial attachment. Aquatic Microbial Ecology. Aquat. Microb. Ecol. 31, 175-182. [S. R. Kelly, E. Garo, P. R. Jensen, T. P. Henkel, W. Fenical and J. R. Pawlik]

Glactolipids rather than phlorotannins as herbivore-deterrents in the brown Seaweed Fucus vesiculosus. Oecologia 136, 107-114. [M. S. Deal, M. E. Hay, D. Wilson, W. Fenical]

Are there activated chemical defenses in sponges of the genus Aplysina from the Caribbean? Mar. Ecol. Prog. Series 246, 127-135. [M. Puyana, W. Fenical and J. R. Pawlik] Mar. Ecol. Prog. Ser.

Halovirs A-E, new antiviral agents from a marine-derived fungus of the genus Scytalidium. Bioorg. Med. Chem. 11, 4263-4274. [D. C. Rowley, S. Kelly, C. A. Kauffman, P. R. Jensen, and W. Fenical]

New neoverrucosane diterpenoids produced by the marine gliding bacterium Saprospira grandis. J. Nat. Prod. 66, 818-822. [A. Spyere, D. C. Rowley, P. R. Jensen and W. Fenical]

A cyclic carbonate and related polyketides from a marine-derived fungus of the genus Phoma. Phytochemistry 64,571-574. [Z. Liu, P. R. Jensen and W. Fenical]

Scytlidamides A and B, new cytotoxic cyclic heptapeptides from a marine fungus of the genus Scytalidium. J. Org. Chem. 68(23), 8767-8773. [L. T. Tan, X. C. Cheng, P. R. Jensen and W. Fenical]

New anticancer drugs from cultured and collected marine organisms. Pharmaceutical Biology 41, 6-14. [W. Fenical, P. R. Jensen, C. Kauffman, S. L. Mayhead, D. J. Faulkner, C. Sincich, M. Rama Rao, E. J. Kantorowski, L. M. West, W. K. Strangman Y. Shimizu, B. Li , S. Thammann, K. Drainville, M. T. Davies-Coleman, R. A. Kramer, C. R. Fairchild, W. C. Rose, R. C. Wild, G. D. Vite, R. W. Peterson]

2004

Marine microorganisms and natural product drug discovery. Current Drug Discovery. [P. R. Jensen and W. Fenical] Jan 1-3.

Capisterones A and B from the tropical green alga Penicillus capitatus: unexpected anti-fungal defenses targeting the marine pathogen Lindra thallasiae. [M. P. Puglisi, L. T. Tan, P. R. Jensen, and W. Fenical] Tetrahedron 60:7035-7039.

Synthesis and structure-activity relationships of the halovirs, antiviral natural products from a marine-derived fungus. Bioorg. Med. Chem. 12, 4929-4936. [D. C. Rowley, S. Kelly, P. Jensen and W. Fenical]

Isolation and structure assignments of the rostratins A-D, cytotoxic disulfides produced by the marine-derived fungus Exserohilum rostratum (Dreschler). J. Nat. Prod. 67(8), 1374-1382. [R. X. Tan, P. R. Jensen, P. G. Williams and W. Fenical]

Phylogenetic analyses and diterpenoid production by marine bacteria of the genus Saprospira. Current Microbiology 49, 300-307. [T. J. Mincer, A. Spyere, P. R. Jensen and W. Fenical]

Crystal structure of the microbial antibiotic A80915C. Acta Crystallographica, sect. E. [I. E. Soria-Mercado, P. R. Jensen and W. Fenical]

Ambiguous role of phlorotannins as chemical defenses in the brown alga Fucus vesiculosus. Marine Ecology: Progress Series, 277, 79-93. [Kubanek, Julia; Lester, Sarah E.; Fenical, William; Hay, Mark E.]

Fluorescent profiling of natural product producers. J. Am. Chem. Soc. 127(26) 9320-9321. [J. S. Sandler, W. Fenical, B. M. Gulledge, A. R. Chamberlin, J. J. La Clair]

2005

Marine actinomycete diversity and natural product discovery. Antonie Van Leeuwenhoek, 87, 43-48.[P. R. Jensen, T. J. Mincer, P. G. Williams, W. Fenical]

Structure-activity relationship studies of Salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor. J. Med. Chem. 48, 3684-3687. [V. R. Macherla, S. S. Mitchell, R. R. Manam, K. A. Reed, T-H. Chao, B. Nicholson, G. Deyanat-Yazdi, B. Mai, P. R. Jensen, W. Fenical, S. T. C. Neuteboom, K. S. Lam, M. A. Palladino, B. C. M. Potts]

Effects of Caribbean sponge extracts on bacterial surface colonization. Aquatic Microbial Ecol. 40:191-203 [S.R. Kelly, P. R. Jensen, T. P. Henkel, W. Fenical, and J. R. Pawlik.

New natural product diversity from marine actinomycetes. [P. R. Jensen and W. Fenical], In: Natural Products, Drug Discovery and Preventive Medicine. L. Zhang and A. L. Demain Eds. Humana Press, 2004.

Antibiotic terpenoid chloro-dihydroquinones from a new marine actinomycete (Streptomycetacea). J. Nat. Prod. [I. E. Soria-Mercado, Alejandra Prieto-Davo, P. R. Jensen, and W. Fenical]

New cytotoxic salinosporamides from the marine actinomycete Salinispora tropica. J. Org. Chem. 70(16), 6196-6203. [P. G. Williams, G. O. Buchanan, R. H. Feling, C. A. Kauffman, P. R. Jensen, W. Fenical]

Salinispora gen nov., a home for obligate marine actinomycetes belonging to the family Micromonosporaceae. Sys. Appl. Microbiol. 55, 1759-1776. [L. Maldonado, W. Fenical, M. Goodfellow, P. R. Jensen, A. C. Ward]

Libertellenones A-D: Induction of cytotoxic diterpenoid biosynthesis by marine microbial competition. Bioorg. Med. Chem 13(17), 5267-5273. [D. C. Oh, P. R. Jensen, C. A Kauffman, and W. Fenical]

Culturable marine actinomycete diversity from tropical Pacific Ocean sediments. Environ Microbiol 7, 1039-48. [Jensen, P. R., Gontang, E., Mafnas, C, Mincer, T. J. & Fenical, W.]

2006

Sporolides A and B: structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica. Org. Lett. 7(13) 2731-34. [G.O. Buchanan, P.G. Williams, R. H. Feling, C. A. Kauffman, P. R. Jensen, W. Fenical]

Culture dependent and culture-independent diversity within the obligate marine actinomycte Salinispora. Appl. Environ Microbiol 71, 7019-28. [T. J. Mincer, W. Fenical, P. R. Jensen*]

A central strategy for converting natural products into fluorescent probes. ChemBioChem 7, 409-416. [J. J. La Clair, M. Alexander, M. D. Burkart, M. S. Leonard, P. Poortonovo, B. Liang, X. Ding, M. M. Joullie, B. M Gulledge, J. B. Aggen, A. R. Chamberlin, J. Sandler, W. Fenical, J. Cui, S. J. Gharpure, A. Polosaukhin, H-R. Zhang, P. A. Andrews, A. D. Richardson, M. K. Harper, C. M. Ireland, B. G. Vong, T. P. Brady and E. A. Theodorakis]

Cyanosporasides A and B, chloro- and cyano-cyclopenta[a]indene glycosides from the marine actinomycete Salinispora “pacifica.” Org. Lett. 8(6), 1021-24. [D.-C. Oh, P. G. Williams, C. A. Kauffman, P. R. Jensen, and W. Fenical]

Marinomycins A-D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus "Marinispora". J. Am. Chem. Soc. 128(5), 1622-1632. [H. C. Kwon, C. A. Kauffman, P. R. Jensen, W. Fenical]

Actinofuranones A and B, polyketides from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales) J. Nat. Prod. 69(3), 425-428. [J.Y. Cho, H. C. Kwon, P. G. Williams, C. A. Kauffman, P. R. Jensen and W. Fenical]

Azamerone, a terpenoid phthalazinone from a marine-derived bacterium related to the genus Streptomyces (Actinomycetales). Org. Lett. 8(12) 2471-2474. [J.-Y. Cho, H.-C. Kwon, P. G. Williams, P. R. Jensen, W. Fenical].

Tropolactones A-D, four new meroterpenoids from a marine-derived fungus of the genus Aspergillus. Phytochem. 67(16), 1826-1831 [M. Cueto, J. B. MacMillan, P. R. Jensen and W. Fenical]

Marine pharmaceuticals: past, present and future, Oceanography 19(2) 110-119. [W. Fenical].

Antimicrobial activities of extracts from tropical atlantic marine algae and seagrasses against marine pathogens and saprophytes. Mar. Biol. 149, 991-1002. [S. Engel, M. P. Puglisi, P.R. Jensen, and W. Fenical]

Antimicrobial activities of extracts from Indo-Pacific marine plants against marine pathogens and saprophytes. Mar. Biol. [M. P. Puglisi, S. Engel, P. R. Jensen, and W. Fenical]

Cytotoxic macrolides from a new species of the deep-water marine sponge Leiodermatium. J. Org. Chem. 71(22) 8684-92. [J. S. Sandler, P. L. Colin, M. Kelly, W. Fenical]

2007

Piperazimycins: cytotoxic hexadepsipeptides from a marine-derived bacterium of the Genus Streptomyces. J. Org. Chem. 72(2),323-330. [E. D. Miller, C. A. Kauffman, P. R. Jensen and W. Fenical]

New bohemamines from a marine-derived Streptomyces sp. J. Nat. Prod. 69, 1626-1628. [T. S. Bugni, M. Woolery, C. A. Kauffman, P. R. Jensen, W. Fenical]

Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora. Appl. Env. Micro. 73(4), 1146-1152 [P. R. Jensen, P. G. Williams, D.-C. Oh, L. Zeigler, and W. Fenical].

Culturable marine actinomycete diversity from tropical Pacific Ocean sediments. Environ. Microbiol. 7:1039-1048. [Jensen, P.R., Gontang, E., Mafnas, C., Mincer, T.J., Fenical, W.]

Marine actinomycete bacteria, developing a new resource for drug discovery. Nat. Chem. Biol. 2, 666-673. [P. R. Jensen and W. Fenical]

Zygosporamide, a cytotoxic cyclic depsipeptide from the marine-derived fungus Zygosporium masonii. Tetrahedron Lett. 47, 8625-8628. [D.-C. Oh, P. R. Jensen, and W. Fenical]

Daryamides A−C, weakly cytotoxic polyketides from a marine-derived actinomycete of the enus Streptomyces, strain CNQ-085. J. Nat. Prod. 69(12) 1756-1759. [R. N. Asolkar, P. R. Jensen, C. A. Kauffman, and W. Fenical]

Phylogenetic diversity of gram-positive bacteria cultured from marine sediments. Appl. Env. Micro. 73(10), 3272-3282. [E. Gontang, W. Fenical and P.R. Jensen]

Anti-predatory secosterols from the octocoral Pseudopterogorgia americana. Mar. Ecol. Prog. Ser. 329, 307-310. [R.A. Epifanio, L. F. Maia, J. R. Pawlik, W. Fenical]

Saliniketals A and B: novel bicyclic polyketides from the marine actinomycete Salinispora arenicola. J. Nat. Prod. 70(1), 83-87. [P. G. Williams, R. N. Asolkar, P. R. Jensen, W. Fenical]

Microsporins A and B: new histone deacetylase inhibitors from the marine-derived fungus Microsporum cf. gypseum and the solid-phase synthesis of microsporin A. Tetrahedron. 63, 6535-6541. [W-X. Gu, M. Cueto, P. R. Jensen, W. Fenical, R. B. Silverman]

Thalassospiramides A and B, immunosuppressive peptides from the marine bacterium Thalassospira sp. Org. Lett. 9(8), 1525-1528. [D.-C. Oh, W. K. Strangman, C. A. Kauffman, P. R. Jensen, and W. Fenical]

Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc. Natl. Acad. Sci. 104(25), 10376. [D. W. Udwary, L. Zeigler, R. N. Asolkar, V. Singan, A. Lapidus, W. Fenical, P. R. Jensen, B. S. Moore]

Secondary metabolite chemistry of the marine-derived fungus Massarina sp., strain CNT-016. Phytochem. 68(8), 1212-1218. [M. A. Abdel-Wahab, R. N. Asolkar, P. Inderbitzin, and W. Fenical]

Induced production of the emericellamides A and B, from the marine-derived fungus Emericella sp. in competing co-culture. J. Nat. Prod. 70(4), 515-520. [D.-C. Oh, C. A. Kauffman, P. R. Jensen, and W. Fenical]

Arenicolides A-C, 26-membered ring macrolides from the marine actinomycete Salinispora arenicola. J. Org. Chem. 1 Feb: asap 17266372. [P. G. Williams, E. D. Miller, R. N. Asolkar, P. R. Jensen and W. Fenical]

Isolation of lucentamycins A-D, cytotoxic peptides from the marine-derived actinomycete Nocardiopsis lucentensis. J. Nat. Prod. 70(8) 1321-1328. [J.-Y. Cho, P. G. Williams, H.-C. Kwon, P. R. Jensen and W. Fenical]

Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces. J. Nat. Prod. 70, 1406–1409 [G. D. A. Martin, L. T. Tan, R. Encarnacion Dimayuga, C. R. Fairchild, P. R. Jensen and W. Fenical]

2008

The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp. Org. Lett. 10(4), 629-631. [C. C. Hughes, A. Prieto-Davo, P. R. Jensen, and W. Fenical*]

Biosynthetically-complex polyketides from the marine actinomycete “Salinispora pacifica” J. Nat. Prod. [D-C. Oh, C. A. Kauffman, P. R. Jensen, W. Fenical]

Biosynthesis and structures of cyclomarins and cyclomarazines, prenylated cyclic peptides of marine actinobacterial origin. J. Am. Chem. Soc., 130(13), 4505-451. [A. W. Schultz, D-C. Oh, J. R. Carney, R. T. Williamson, D. W. Udwary, P. R. Jensen, S. J. Gould, W. Fenical, and B. S. Moore]

Marine Actinomycetes: A New source of compounds against the human malaria parasite. PLoS One, 2008, 3(6) e2335. [J. Prudhomme1, E. McDaniel, N. Ponts, S. Bertani, W. Fenical, P. R. Jensen3, and K. Le Roch]

Actinomycete diversity in marine sediments. Aquatic Micro. Ecol. 2008. 52, 1-11. [A. Prieto-Davó, W. Fenical and P. R. Jensen*]

Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. 2008. J. Am. Chem. Soc. 30 (25), 7822–7823. [R. P. McGlinchey, M. Nett, A. S. Eustáquio, R. N. Asolkar, W. Fenical, and B. S. Moore]